It's such a sad story because I grew up in the 80s and she was a mega movie star back then. That voice, the sex appeal, the fact she was such a versatile actress, from action to comedy to drama, she was accomplished in everything. I loved her performances in Peggy Sue Got Married and The War of the Roses, so good in those movies.
Then she got sick and the medication she needed to take care of her health made her gain a lot of weight which meant she was no longer "hot" and the roles evaporated. She did a couple of decent movies, best being Serial Mom and The Virgin Suicides as well as a successful run on the West End with The Graduate but her hey day was over.
It always surprises me how you can be huge in one year and then a nobody the next. Katherine Heigl is another example, she was the Julia Roberts of the 2000s, then she got mouthy, she was over.